Having worked in the new home industry for 10 years, if there was something I noticed over and over agin when looking at the floor plans of the homes I sold- poor use of space The layouts were not designed properly.
Once I moved over to the interior design side of things, I could help my Client's who were building new homes much easier when it came down to this big issue. Keep in mind not all home builders are the same, and not all are going to make structural changes, but if you are building a custom or even semi custom home, knowing this design mistake ahead of time will save you from a lot of headaches down the road.
This will provide flexibility for entertaining. Place the kitchen and the living at opposite ends of the entire space for noise buffering, while keeping the openness of vision.